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You can read additional information about the A4 Study on the A4 Study website!


What is the A4 Study?
The A4 Study is a clinical study for older individuals (ages 65-85) who have normal thinking and memory function but who may be at risk for developing Alzheimer's disease (AD) memory loss sometime in the future. The A4 study is for people without any outward signs of Alzheimer's disease, and is designed to evaluate the effectiveness, safety and tolerability of an investigational drug for AD. The purpose of the Anti-Amyloid Treatment in Asymptomatic Alzheimer’s study (the”A4 study” for short) is to test whether a new investigational treatment can slow the memory loss caused by Alzheimer’s disease. The overall goal of the A4 study is to test whether decreasing amyloid with antibody investigational treatment can help slow the memory loss associated with amyloid buildup in some people.

The A4 Study lasts for three years, and participants will be assigned at random to receive either the investigational drug or a placebo and will be monitored over that period.

In general, you may be eligible to join the A4 Study if you:

  • Are 65 to 85 years old
  • Have normal thinking and memory abilities
  • Have a study partner (someone who has weekly contact with you and is willing to answer questions once a year).

The A4 Study will begin to enroll participants at more than 60 sites throughout the U.S. and Canada and in Australia beginning in the Spring of 2014. Please visit for additional information. We expect sites across North America to be ready to screen and enroll study participants during the first half 2014.

Meet the A4 Principal Investigator

Reisa Sperling, M.D. is a Professor in Neurology at Harvard Medical School and the Director of the Center for Alzheimer Research and Treatment at Brigham and Women’s Hospital. She is a board certified neurologist who has been working in cognitive aging and Alzheimer's disease research for over 15 years. Her imaging work is focused on elucidating the neural underpinnings of memory loss and detecting the earliest brain changes associated with early Alzheimer's disease. She is the Principal Investigator on a National Institute on Aging (NIA) funded Program Project: the Harvard Aging Brain Study and serves as the Director of the Alzheimer’s Disease Neuroimaging Program at Massachusetts General Hospital. Dr. Sperling had the honor of serving as the Chair of the NIA-Alzheimer’s Association working group to develop the research criteria for “Preclinical Alzheimer’s disease” published in 2011.

Dr. Sperling leads the is the Project Director of the A4 Study . You can learn more about Dr. Sperling’s work by following the link below to the Massachusetts ADRC.

Who is sponsoring the A4 Study?

The A4 study is a landmark public-private partnership, funded by the National Institute on Aging, Eli Lilly and Company, and several philanthropic organizations. The A4 trial is coordinated by the Alzheimer's Disease Cooperative Study, located at the University of California, San Diego.

Contact the A4 Study

(Please note that due to a high level of interest in the A4 study, there may be a delay in sites responding to inquiries. Every effort is being made to follow up with potential participants as quickly as possible. To help speed the process, please contact study sites by email versus phone, if possible. We thank you for your interest in the A4 study.)

U.S. Clinical Study Research Sites Participating in the A4 Study:

ALBirminghamUniversity of Alabama, BirminghamDenise Ledlow(205)
AZPhoenixBanner Alzheimer's InstituteRoma Patel(602)
AZSun CityBanner Sun Health Research InstituteZoran Obradov(623)
AZTucsonArizona Health Sciences Center   
CAIrvineUniversity of California, IrvineBeatriz Yanez(949)
CALa JollaUniversity of California, San DiegoChristina Gigliotti(858)
CALos AngelesUniversity of Southern CaliforniaMauricio Becerra(323)
CALos AngelesUniversity of California, Los AngelesCeline Ossinalde(310)
CAOrangeUniversity of California, Irvine - Neuropsychiatric CenterAndrea Weideman(714)
CAPalo AltoStanford University School of MedicineTamara Beale(650)
CASan DiegoPacific Research NetworkBud Gaydos(619)
CASan FranciscoUniversity of California, San FranciscoEmmeline Chuu(415)
CASanta AnaSyrentis Clinical Research   
CAWalnut CreekUniversity of California, DavisRenee Reza(925)
CTNew HavenYale University School of MedicineJulia McDonald(203)
DCWashingtonHoward UniversitySaba Wolday(202)
DCWashingtonGeorgetown UniversityErica Christian(202)
FLJacksonvilleMayo Clinic, JacksonvilleDana Haley(904)
FLLady LakeCompass Research NorthJoleen Smith(352)
FLMiami BeachWien Center for Clinical ResearchMaria Greig-Custo(305)674-2121 ext
FLOrlandoCompass Research, OrlandoRina Ashby(407)
FLPalm BeachPremiere Research InstituteDaisy Acevedo(561)845-0500 ext
FLTampaUniversity of South Florida - Health Byrd Alzheimer InstituteKelly Rodrigo(813)
GAAtlantaEmory UniversityDeborah Westover(404)
IAIowa CityUniversity of IowaKaren Smith(319)
ILChicagoNorthwestern UniversityKristine Lipowski(312)
ILChicagoRush University Medical CenterMary Messenger(312)
INIndianapolisIndiana UniversityNancy McClaskey(317)
KSKansas CityUniversity of KansasAiden Bondurant(913)
KYLexingtonUniversity of KentuckySarah Tarrant(859)
LABaton RougePennington Biomedical Research CenterAmy Thomassie(225)
MABostonBrigham and Women's HospitalAlison Pietras(617)
MABostonBoston UniversityJane Mwicigi(617)
MDBaltimoreJohns Hopkins UniversitySarah Woody(410)
MIAnn ArborUniversity of Michigan, Ann ArborKathryn Steen(734)
MNRochesterMayo Clinic, RochesterSara Mason(507)
MOSt. LouisWashington University, St. LouisErin Cattoor(314)
NCWinston-SalemWake Forest University Health SciencesPatricia Wittmer(336)
NEOmahaUniversity of Nebraska Medical CenterMary Horrum(402)
NEOmahaUniversity of Nebraska Medical CenterBarbara Bayer(402)
NVLas VegasCleveland Clinic Lou Ruvo Center for Brain HealthMilagros Formoso(702)
NYAmherstDent Neurologic InstituteCaroline Kumm(716)
NYNew YorkColumbia UniversityRuth Tejeda(212)
NYNew YorkNew York University Medical CenterBrittany Cerbone(212)
NYNew YorkMount Sinai School of MedicineKelly Pun(212)
NYNew YorkWeill Cornell Memory Disorders ProgramGabriella Arth(212)
NYOrangeburgNathan Kline Institute for Psychiatric ResearchRaymundo Hernando(845)
NYRochesterUniversity of Rochester Medical CenterSusan Salem-Spencer(585)
OHClevelandCase Western Reserve UniversityMaria Gross(216)
OKTulsaTulsa Clinical ResearchChristy Lisenbee(918)
ORPortlandOregon Health & Science UniversityAllison Bianchi(503)
PAPhiladelphiaUniversity of PennsylvaniaJessica Nunez-Lopez(215)
PAPhiladelphiaDrexel University College of MedicineKatie Rife(215)
PAPittsburghUniversity of PittsburghKaty Zorich(412)
RIProvidenceButler Hospital Memory and Aging ProgramDiane Monast(401)
RIProvidenceRhode Island HospitalKerstin Calia(401)
SCCharlestonRoper St. Francis HospitalCatherine Danner & Jessica Huggins(843) &
TXDallasUniversity of Texas, Southwestern MC at DallasErica Adkins(214)
TXHoustonBaylor College of MedicineSydney O'Connor(713)
TXHoustonHouston Methodist Neurological Institute   
WASeattleUniversity of WashingtonAnita Ranta(206)
WIMadisonUniversity of WisconsinBen Farral(608)256-1901 ext

Canada Clinical Study Research Sites Participating in the A4 Study:

British ColumbiaVancouverUniversity of British Columbia, Clinic for AD & RelatedBenita Mudge(604)
OntarioLondonParkwood HospitalPatricia Sargeant+519)685-4292 Ext.
OntarioTorontoToronto Memory ProgramTamara Boric(416)
OntarioTorontoSunnybrook Health Sciences CentreJoanne Lawrence+416)

Australia Clinical Study Research Sites Participating in the A4 Study:

VictoriaMelbourneUniversity of MelbourneMaree Mastwyk+61 3 9389