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A mandate of the ADCS is to develop optimal assessment instruments for use in clinical trials. Virtually every current AD trial uses one or more instruments developed by the ADCS. We have experience with a variety of instruments that measure cognitive, functional, global, resource use, and quality of life status. Since 1996 these instruments have been requested by over 500 academic or commercial entities.

The instruments most frequently requested are the Alzheimer's Disease Assessment Scale-Cognitive subscale (ADAS-cog), Activities of Daily Living (ADL), and the Clinical Global Impression of Change Scale (CGIC). Some are also available in Spanish and alternative versions. Licensing, copyright and/or permission for use rules may apply.

For further information or to request an instrument, contact: ADCS ClinOps Support

ADAS-Cog Testing Kits

One of the mandates of the ADCS is to help to standardize assessments used in Alzheimer's Disease (AD) clinical trials. This includes collaborating with the developers of existing assessments as well as developing new instruments that would benefit the field. This includes the ADAScog (Alzheimer's Disease Assessment Scale - Cognitive Subscale), developed by Drs. Rosen, Mohs and colleagues in 1984.

When the ADCS was established in 1992, we embarked on our first NIH-funded clinical trial (NEJM, 1997:336:1216-22). In organizing and preparing for this study, we found that there was no central source for procuring the ADAScog testing kits. We were extremely fortunate that Dr. Richard Mohs, one of the developers of the ADAScog, was the Chair of the ADCS Cognitive Scales Committee. We worked closely with Dr. Mohs to create an ADAScog testing kit that met his specifications and approval. These kits were initially developed solely for ADCS use, and continue to be used in all ADCS clinical trials.

As our clinical monitors and ADCS staff conducted on-site visits, starting in 1992, we noticed a large variation in the quality and content of ADAScog kits used at sites for non-ADCS studies. Study Coordinators would often show us the kits supplied by sponsors, noting that the ADCS-provided kits had far better quality items, and were standardized across ADCS studies. We were shown naming items from other sponsors that included harmonicas with the word "harmonica" printed on them, toy plastic stethoscopes that were multi-neon colored and nearly unrecognizable to us, flowers that were clearly roses, and other similar examples that would impact the patients' performance and hence score on the naming portion of the ADAScog.

After discussion with Drs. Leon Thal and Richard Mohs, it was determined that it would be appropriate and beneficial for the ADCS to help standardize the ADAScog testing kits, and make them widely available at our cost to outside sponsors. This effort was consistent with the NIH mandate that the ADCS assist with standardizing assessments used in AD clinical trials.

For the past 12 years, the ADCS has produced and supplied standardized ADAScog testing kits to sponsors. We now feel that we have fulfilled our mission and the kits have been successfully standardized, under the direction and approval of Dr. Richard Mohs. As of September 1, 2009, the ADCS will no longer be directly supplying the ADAScog kits. However, the vendor we have worked with since 1992, Prepress Type and Graphics (, 619-528-0800), will continue to produce the standardized kits.

The ADCS will continue our commitment to maintaining best practices for cognitive assessment in AD. We will continue to provide guidance on administration, scoring and analysis of the ADAScog, through academic publications and materials disseminated on our website We will also continue to serve as a resource for the AD research community by answering any questions regarding the ADAScog itself or the standardized kits.

If you have questions, please email ADCS ClinOps Support.