Alzheimer's Disease Cooperative Study

Data Sharing

If you are interested in utilizing ADCS trial data, please review the ADCS Data Access Policy. Access to ADCS trial data remains restricted until the study's primary manuscript has been published. For the first year following publication, the study's data is available only to members of the ADCS Steeering Committee. After that time, any investigator may apply for access. To apply for access, complete the ADCS Data Access Request Form and submit to ADCSdataaccess@ucsd.edu.

For more information on access to ongoing studies, visit the Study Resources Page

NOTES:
* "OPEN" status projects are initially available for steering committee members and becomes available to the public 1 year following the publication date.
** Link to primary publication will be added once it is made available.

Protocol Number	Protocol Name	Study Duration	Treatment	Diagnostic Group(s)	Instruments/Biomarkers	Actual Baselined	Primary Paper Publication Date	Data Portal Status
ADC-001	Selegiline(SL)	24 months	Selegiline or a-Tocopherol or Selegiline Placebo and a-tocopherol or selegiline and a-tocopherol placebo or Placebo	AD	ADASCog, Blessed DRS, Blindness Eval, CDR, CERAD, ADL & Dependency Scale, Hackinski, MMSE, Modified UPDRS	BL=341	04/1997 (Link to PubMed)	Open Data Portal (Forgot password)
ADC-002	New Instruments Trial(IN)	12 months	Non-Drug Study	AD, NL	ADL, CDR, CERAD, CGIC, CMAI, Hachinski, Executive Function, Facial Recognition, Letter Cancellation, Functional Assessment Staging, GDS, MMSE, Praxis, Severe Impairment Battery, Verbal Memory Immediate & Delayed Recall	BL=306	06/1997 (Link to PubMed)	Open Data Portal (Forgot password)
ADC-002	New Instruments Trial (Spanish)(IN)	12 months	Non-Drug Study	AD, NL	ADL, CDR, CERAD, CGIC, CMAI, Hachinski, Executive Function, Facial Recognition, Letter Cancellation, Functional Assessment Staging, GDS, MMSE, Praxis, Severe Impairment Battery, Verbal Memory Immediate & Delayed Recall	BL=94	06/1997 (Link to PubMed)	Open Data Portal (Forgot password)
ADC-003	Agitation(AP)	24 months	Haloperidol or Trazodone or Behavior Techniques or Placebo	AD	APOE, Abnormal Involuntary Movement Scale, Blindness Eval, CGIC, CMAI, CERAD, CMAI, Hackinski, MMSE, Lawton and Brody ADL	BL=149	11/2000 (Link to PubMed)	Open Data Portal (Forgot password)
ADC-004	Prednisone(PR)	68 weeks	Prednisone or Placebo	AD	ADASCOG, ADASRECALL, ADAS RECOGNITION, APOE, Blessed Dimentia Rating, BPRS, Blindness Eval, CDR, Dependency Scale, HDRS, Hachinski, Lumbar, MMSE, UPDRS	BL=138	02/2000 (Link to PubMed)	Open Data Portal (Forgot password)
ADC-005	Estrogen(ES)	12 months, plus 3 Months wash-out	Estrogen(Premarin) or Placebo	AD	ADASCog, ADASRECALL, ADAS RECOGNITION, APOE, Blindness Eval, BDRS, CDR, CSF, CGIC, Dependence Scale, Emotional Recognition, Hachinski, Hamilton, Lumbar Puncture, MAACL, MMSE, Newdot, QOL, Trailpeg, UPDRS	BL=120	02/2000 (Link to PubMed)	Open Data Portal (Forgot password)
ADC-007	Melatonin(ML)	8 weeks, plus 2 Weeks placebo washout	Melatonin or Placebo	AD	ADASCog, ADAS RECOGNITION, ADASRL, ADL, APOE, Blindness Eval, COSTINF, EMOTION, Hamilton, Hachinski, MMSE, NPI, Parasomnia Questionnaire, QOL, Sleep Disorder Inv, UPDRS	BL=157	11/2003 (Link to PubMed)	Open Data Portal (Forgot password)
ADC-008	Mild Cognitive Impairment(MCI)	36 months, plus 4 months donepezil visits	Vitamin E or Donepezil HCL (Aricept) or Placebo	MCI	ADACog, ADL, APOE/DNA Storage, Beck, Blindness Eval,MCI-CGIC, CDR, CT/MRI, GDS, Hamilton, Hachinski, Logical Memory I and II, MMSE, Neuropsychological Battery, Oxidative Biomarkers/DNA Storage, QOL, RUI	BL=769	06/2005 (Link to PubMed)	Open Data Portal (Forgot password)
ADC-010	Normal Control(NL)	36 months	Non-Drug Study	NL	ADACog, ADL, APOE/DNA Storage, Beck, Blindness Eval, Cleveland QOL, CGIC, CDR, GDS, Hamilton, Hachinski, Logical Memory I and II, MMSE, Neuropsychological Battery, QOL, RUI	Target Enrollment=100	Pending	Restricted Data Portal (Forgot password)
ADC-011	NSAIDS / Non-Steroidal(NS)	12 months plus 2 months wash-out	Rofecoxib or Naproxen or Placebo	AD	ADASCog, ADL, APOE/DNA, Blindness Eval, CDR, CT/MRI, Hachinski, MMSE, NPI, QOL, RUI	BL=351	06/2003 (Link to PubMed)	Open Data Portal (Forgot password)
ADC-012	Valproate(VP)	6 weeks, plus 6 weeks open label	Divalproex Sodium or Placebo	AD	BPRS, CMAI, Hachinski, MMSE	BL=153	11/2005 (Link to PubMed)	Open Data Portal (Forgot password)
ADC-013	Prevention Instruments(PI)	48 Months	Non-Drug Study	MCI, NL	ADL, APOE/DNA Storage, Behavioral Scale, Boston Naming, CDR, CGIC-IRPV, CGIC-SAPV, Cognitive Scale, Efficiency, Free and Cued Selective Reminding, GDS, Cognitive Function Screening Instruments, QOL, MMSE, NPI, NYU Paragraph, RUI, Trails A & B and WAIS-R	BL=662	Pending	Restricted Data Portal (Forgot password)
ADC-013	Prevention Instruments - Web Based(PIWEB)	48 Months	Non-Drug Study	MCI, NL	ADL, APOE/DNA Storage, Behavioral Scale, Boston Naming, CDR, CGIC-IRPV, CGIC-SAPV, Cognitive Scale, Efficiency, Free and Cued Selective Reminding, GDS, Cognitive Function Screening Instruments, QOL, MMSE, NPI, NYU Paragraph, RUI, Trails A & B and WAIS-R	BL=55	Pending	Restricted Data Portal (Forgot password)
ADC-014	TAP/DAP or Diffuse Lewy Body(TA)	10 weeks	Quetiapine(Seroquel) or Donepezil (Aricept) or Quetiapine(Seroquel) and Donepezil (Aricept) or Placebo	AD, DLB	ADL, BPRS, CGIC, MMSE, NPI, R-MDS-D, UPDRS	BL=40	04/2007 (Link to PubMed)	Open Data Portal (Forgot password)
ADC-015	Simvastatin (LL)	18 months	Simvastatin or Placebo	AD	ADASCog, APOE/DNA Storage, Blindness Eval ,CGIC, Dependency Scale, Hachinski, MMSE, NPI, QOL, RUI	Target enrollment=406	08/2011 (Link to PubMed)	Open Data Portal (Forgot password)
ADC-016	Homocysteine(HC)	18 months	Folate, Vitamin B6, Vitamin B12 or Placebo	AD	ADASCog, ADL, APOE/DNA Storage, Blindness Eval, CDR, CT/MRI, Hachinski, QOL, MMSE, NPI, RUI	BL=409	10/2008 (Link to PubMed)	Open Data Portal (Forgot password)
ADC-022	Valproate Neuroprotection(VN)	24 months. Plus 2 months wash-out	Valproate or Placebo	AD	ADL, ADASCog, APOE, CDR, CGIC, Biomarker, ClinEval, CDR, CMAI, CT/MRI, Family History, MMSE, NPI, QOL	Target enrollment=300	08/2011 (Link to PubMed)	Open Data Portal (Forgot password)
ADC-023	Huperzine(HU)	24 weeks,plus Open Label Phase I up to 48 weeks, and Open Label Phase II up to 72 weeks.	Huperzine A or Placebo	AD	ADASCog, ADL, Blindness Eval, CGIC, CT/MRI, Hachinski, MMSE, NPI	BL=210	04/2011 (Link to PubMed)	Open Data Portal (Forgot password)
ADC-025	Antioxidant(AX)	16 weeks plus followup phone call	Vitamin E plus Vitamin C plus a-Lipoic Acid and Coenzyme Q, or Placebo	AD	ADL, Biomarkes, BPRS, GDS, Hachinski, Lumbar Puncture, MMSE	Target enrollment=75	07/2012 (Link to PubMed)	SC Only Data Portal (Forgot password)
ADC-027	Docosahexaenoic Acid(DHA)	18 months	Docosahexaenoic Acid or Placebo	AD	ADAS-Cog, ADCS-ADL, APOE, CDR-SOB, FFQ, Hachinski, Lumbar puncture, MMSE, MRI, NPI, QOL	BL=402	11/2010 (Link to PubMed)	Open Data Portal (Forgot password)

| Contact Us |